B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
B01J 13/02 (2006.01) A61K 9/14 (2006.01)
Patent
CA 2532837
The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01~m to about 200~m.
La présente invention concerne un procédé pour préparer de petites particules sphériques d'agent actif en introduisant une solution dans une phase liquide unique. La phase liquide unique comprend un agent actif, un agent d'amélioration de séparation de phases, et un premier solvant. Un changement de phase est induit à une vitesse contrôlée dans la solution afin de provoquer une séparation phase solide/phase liquide de l'agent actif et de former une phase solide et une phase liquide. La phase solide comprend de petites particules sphériques de l'agent actif. La phase liquide comprend l'agent d'amélioration de séparation de phases et le solvant. Les petites particules sont sensiblement sphériques et ont une taille d'environ 0,01 ?m à environ 200 ?m.
Brown Larry
Mc Geehan John K.
Rashba-Step Julia
Scott Terrence L.
Baxter Healthcare S.a.
Baxter International Inc.
Sim & Mcburney
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