C - Chemistry – Metallurgy – 08 – J
Patent
C - Chemistry, Metallurgy
08
J
C08J 3/14 (2006.01) A61K 9/16 (2006.01) C08L 3/12 (2006.01) C08L 5/00 (2006.01) A61K 9/51 (2006.01)
Patent
CA 2340222
The invention relates to a method for the production of spherical microparticles consisting totally or partly of at least one water-insoluble polysaccharide, wherein the at least one water-insoluble polysaccharide is dissolved in a solvent or solvent mixture, the solution thus formed is introduced into a precipitating agent or precipitating agent mixture, the mixture obtained is optionally cooled and the formed microparticles are separated. The invention is characterized in that the water-insoluble polysaccharide is selected from a polyglucan containing branches with a degree of branching higher than zero and no higher than 8 % and a mixture of a polyglucan containing branches and a linear polysaccharide, wherein the proportion of polyglucan containing branches in the mixture is at the most 30 % by weight in relation to the overall weight of the polysaccharide and the polyglucan.
L'invention concerne un procédé permettant de préparer des microparticules sphériques, consistant en totalité ou en partie en au moins un polysaccharide non soluble dans l'eau. Ledit polysaccharide non soluble dans l'eau (au moins au nombre de un) est dissous dans un solvant ou un mélange de solvants. La solution obtenue est introduite dans un agent de précipitation. Le mélange qui en résulte est éventuellement refroidi et les microparticules formées sont séparées. Ce procédé se caractérise en ce que le polysaccharide non soluble dans l'eau est choisi parmi un polyglucane contenant des ramifications, dont le degré de ramification est supérieur à zéro et atteint au maximum 8 %, et un mélange d'un polyglucane contenant des ramifications et un polysaccharide linéaire. Dans le mélange, la proportion de polyglucane contenant des ramifications représente au maximum 30 % en poids du poids global du polysaccharide et du polyglucane.
Bengs Holger
Grande Jurgen
Axiva Gmbh
Bengs Holger
Fetherstonhaugh & Co.
Grande Jurgen
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