A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2431705
The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of : (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution ; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound ; and (iii) seeding the first solution or the second solvent or the presuspension.
La présente invention concerne un procédé de préparation pour un composé pharmaceutique en suspension dont la solubilité est plus élevée dans un premier solvant organique miscible avec l'eau que dans un second solvant organique aqueux. Ce procédé consiste à: (i) dissoudre une première quantité du composé pharmaceutiquement actif dans un premier solvant organique miscible dans l'eau pour former une première solution; (ii) mélanger la première solution avec le second solvant pour précipiter le composé pharmaceutiquement actif; et (iii) ensemencer la première solution ou le premier solvant ou la pré-suspension.
Brynjelsen Sean
Doty Mark J.
Kipp James E.
Rebbeck Christine L.
Sriram Rajaram
Baxter International Inc.
Sim & Mcburney
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