C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 1/02 (2006.01) C07C 45/71 (2006.01) C07C 47/575 (2006.01) C07C 255/46 (2006.01) C07D 303/48 (2006.01)
Patent
CA 2305614
This invention relates to a method of preparing a compound type where at least one of R' or R'' is a carboxyl group (I) by treating a compound of formula (II) with a Group I(a) or Group II(a) metal halide, with an aprotic dipolar amide-based solvent and water.
L'invention concerne un procédé de préparation d'un composé du type suivant, dans lequel au moins l'un des radicaux R' ou R'' est un groupe carboxyle (I), ledit procédé consistant à traiter un composé de formule (II) avec un halogénure d'un métal du groupe I(a) ou du groupe II(a), un solvant aprotique bipolaire à base d'amide et de l'eau.
Chen Jian-Hoa
Mendelson Wilford
Webb Kevin
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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