Method for preparing taxane derivatives, novel derivatives...

Details Method for preparing taxane derivatives, novel derivatives... Method for preparing taxane derivatives, novel derivatives...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/335 (2006.01) C07D 263/04 (2006.01) C07D 263/52 (2006.01)

Patent

CA 2096833

A method for preparing taxane derivatives having general formula (I), novel derivatives thereby obtained and compositions containing same. In general formula (I), R is t.butoxy or phenyl, R1 is hydrogen or acetyl, and Ar is substituted phenyl or optionally substituted alpha or beta -naphthyl. These novel taxane derivatives are useful as antileukemic and antitumoral agents.

Procédé de préparation de dérivés du taxane de formule générale (I), nouveaux dérivés ainsi obtenus et compositions qui les contiennent. Dans la formule générale (I), R représente t.butoxy ou phényle, R1 représente hydrogène ou acétyle et Ar repré- sente phényle substitué ou .alpha.- ou .beta.-naphtyle éventuellement substitué. Les nouveaux dérivés du taxane sont utiles comme antileu- cémiques et antitumoraux.

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