C - Chemistry – Metallurgy – 08 – J
Patent
C - Chemistry, Metallurgy
08
J
C08J 7/02 (2006.01) A61F 9/00 (2006.01) A61K 9/00 (2006.01) A61P 27/06 (2006.01) B05D 3/12 (2006.01) C08J 3/205 (2006.01) C08J 7/06 (2006.01)
Patent
CA 2510960
The present invention describes a method for the impregnation of a drug or a drug composition into ophthalmic articles, in order to prepare drug sustained release systems mainly for the treatment of glaucoma and other eye diseases. Ophthalmic articles can be for example contact lenses. The drug or drug composition is dissolved in a compressed fluid, or mixture of compressed fluids, in a liquid, sub-critical liquid, gaseous or supercritical state. Co-solvents can be added to increase drug solubility in the compressed fluids. The mixture is subsequently contacted with the ophthalmic article. This process can be done in a single step or in a double step manner. The impregnation can be carried out in finished or semi- finished ophthalmic articles.
Baptista Leite Eugenio Oscar
Cipriano de Sousa Herminio Jose
Cruz Duarte Ana Rita
Martins Duarte Catarina Maria
Mendes Gil Maria Helena
Instituto de Biologia Experimental E. Tecnologica
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universidade de Coimbra
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