Method for preparing thioether conjugates

Details Method for preparing thioether conjugates Method for preparing thioether conjugates

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 47/48 (2006.01) C07D 207/452 (2006.01) C07H 15/26 (2006.01)

Patent

CA 2141277

A method is provided for preparing thioether conjugates useful in treating neoplastic diseases and preferably formed of the BR96 immunoconjugate synthesized from a heterobifunctional linker of doxorubicin, wherein a purified and reduced form of BR96 MAb is conjugated with the 6-maleimidocaproyl hydrazone of doxorubicin and the resulting crude conjugate is purified.

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