Method for preserving liposomes

Details Method for preserving liposomes Method for preserving liposomes

A - Human Necessities

01

N

167/163, 167/322

A01N 25/00 (2006.01) A01N 39/00 (2006.01) A01N 63/02 (2006.01) A61K 9/127 (2006.01) A61K 49/22 (2006.01)

Patent

CA 1275248

Abstract A novel method is provided for preserving liposomes containing biologically active molecules, such that when rehydrated, liposome structures retain substan- tially all material originally encapsulated. A pre- serving agent having at least two nonosaccharide units is used either internally or externally or both. In a preferred embodiment, trehalose is used as a preserving agent, both inside the liposomes as an encapsulate material and externally, in solution, during freeze- drying. The invention also includes a lyophilized com- position prepared by the disclosed method.

499252

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