A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/16 (2006.01) A61K 31/19 (2006.01)
Patent
CA 2441542
Disclosed is a method of treating acute renal failure in a subject. The method comprises the step of administering to the subject an effective amount of a composition comprising a 2-ketoalkanoic acid, a pharmaceutically acceptable salt of a 2-ketoalkanoic acid, an ester of a 2-ketoalkanoic acid, or an amide of a 2-ketoalkanoic acid. Preferably, the composition comprises an enolization agent and an alkyl aralkyl, alkoxyalkyl or carboxyalkyl ester of a 2- ketoalkanoic acid dissolved in a pharmaceutically acceptable vehicle.
L'invention concerne une méthode destinée à traiter une insuffisance rénale aiguë chez un sujet. Cette méthode consiste à administrer à ce sujet une dose efficace d'une composition contenant un acide 2-cétoalcanoïque, un sel pharmaceutiquement acceptable d'un acide 2-cétoalcanoïque, un ester d'un acide 2-cétoalcanoïque, ou un amide d'un acide 2-cétoalcanoïque. De préférence, cette composition contient un agent d'énolisation et un ester alkylaralkyle, alcoxyalkyle ou carboxyalkyle d'un acide 2-cétoalcanoïque dissous dans un véhicule pharmaceutiquement acceptable.
Fink Mitchell P.
Warren H. Shaw
Critical Therapeutics Inc.
Gowling Lafleur Henderson Llp
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