A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01)
Patent
CA 2568427
A method for preventing or treating mammalian diseases mediated by amphiregulin released from mast cells by administering an anti-amphiregulin antibody to a mammal. The antibody binds to the amphiregulin and prevents it from interacting with and activating mammalian cells that are involved in the pathogenesis of diseases. By preventing this binding and activation, the antibody prevents or treats any diseases mediated by amphiregulin released from the mast cells. Preferably, the method is used to prevent or treat allergic diseases, asthma, or fibrosis by reducing the affect of amphiregulin on the cells involved in such diseases.
L'invention concerne une méthode de prévention ou de traitement des maladies des mammifères médiées par l'amphiréguline libérée par les mastocytes, par administration d'un anticorps anti-amphiréguline à un mammifère. L'anticorps se fixe à l'amphiréguline et l'empêche d'interagir avec et d'activer les cellules du mammifère impliquées dans la pathogenèse des maladies. La prévention de la fixation et de l'activation permet à l'anticorps de prévenir ou de traiter toutes les maladies médiées par l'amphiréguline libérée par les mastocytes. La méthode de l'invention est, de préférence, utilisée pour prévenir ou traiter les maladies allergiques, l'asthme ou la fibrose, par réduction de l'effet de l'amphiréguline sur les cellules impliquées dans lesdites maladies.
Hu Guanghui
Wang Shen-Wu
Yao Yhengbin
Genentech Inc.
Sim & Mcburney
Tanox Inc.
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