Method for preventing damage to or rejuvenating a cellular...

A - Human Necessities – 61 – L

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A61L 2/00 (2006.01) A61K 31/525 (2006.01) A61K 35/14 (2006.01) A61K 41/00 (2006.01) A61L 2/08 (2006.01) A61L 2/18 (2006.01) A61M 1/36 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2483046

This invention provides methods for treating cellular blood components and other cells containing mitochondria to improve vital qualities of the cells by contacting the cells with a mitochondrial enhancer to the cells. Mitochondrial enhancers prevent damage to and rejuvenate mitochondria and cells containing mitochondria. Mitochondrial enhancers include alloxazines and related compounds, such as riboflavin. Cells are optionally treated with photoradiation to reduce pathogens with may be present, before, after, and/or during treatment with mitochondrial enhancer. Treating with mitochondrial enhancer enables utilization of higher photoradiation energies, which achieves better pathogen reduction. When platelets are treated with mitochondrial enhancer, treated platelets may be stored for longer times than untreated platelets before they are administered to patients.

La présente invention concerne des procédés permettant de traiter des composants de sang cellulaires et d'autres cellules contenant des mitochondries pour améliorer les qualités vitales des cellules, en plaçant ces dernières en contact avec un amplificateur des micochondries des cellules. Ces amplificateurs évitent l'endommagement et assurent le rajeunissement des mitochondries et des cellules les contenant. Ces amplificateurs comprennent des alloxazines et des composants apparentés, comme la riboflavine. Les cellules sont éventuellement traitées par irradiation laser pour réduire les pathogènes qui peuvent être présents, avant, après et/ou pendant le traitement par l'amplificateur mitochondrial. Le traitement par cet amplificateur permet d'utiliser des énergies d'irradiation supérieures qui assurent une meilleure réduction des agents pathogènes. Lorsque l'on traite les plaquettes par cet amplificateur, les plaquettes traitées peuvent être stockées pendant plus longtemps que les plaquettes non traitées avant leur administration à des patients.

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