Method for preventing hiv-1 infection of cd4+ cells

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) C07K 14/52 (2006.01) C07K 14/715 (2006.01) C07K 17/08 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2250829

This invention provides methods for inhibiting fusion of HIV-1 to CD4+ cells which comprise contacting CD4+ cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4+ cells is inhibited. This invention also provides methods for inhibiting HIV-1 infection of CD4+ cells which comprise contacting CD4+ cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4+ cells is inhibited, thereby inhibiting the HIV-1 infection. This invention provides non-chemokine agents capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4+ cells. This invention also provides pharmaceutical compositions comprising an amount of the non-chemokine agent capable of binding to the chemokine receptor and inhibiting fusion of HIV-1 to CD4+ cells effective to prevent fusion of HIV-1 to CD4+ cells and a pharmaceutically acceptable carrier.

L'invention concerne une méthode permettant d'inhiber la fusion du VIH-1 et des cellules CD4?+¿ et consistant à mettre les cellules CD4?+¿ en contact avec un agent non-chémokine capable de se lier à un récepteur de chémokine dans des conditions et en quantités suffisantes pour inhiber la fusion du VIH-1 et des cellules CD4?+¿. L'invention concerne également une méthode permettant d'inhiber l'infection des cellules CD4?+¿ par le VIH-1 et consistant à mettre les cellules CD4?+¿ en contact avec un agent non-chémokine capable de se lier à un récepteur de chémokine dans des conditions et en quantités suffisantes pour inhiber la fusion du VIH-1 et des cellules CD4?+¿, ce qui permet d'inhiber l'infection par le VIH-1. De même, l'invention décrit des agents non-chémokines capables de se lier au récepteur de chémokine et d'inhiber la fusion du VIH-1 et des cellules CD4?+¿. L'invention concerne finalement des compositions pharmaceutiques comprenant une certaine quantité d'agent non-chémokine capable de se lier au récepteur de chémokine et d'inhiber la fusion du VIH-1 et des cellules CD4?+¿, ainsi qu'un excipient acceptable en pharmacologie.

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