Method for preventing the formation of a crystalline hydrate...

Details Method for preventing the formation of a crystalline hydrate... Method for preventing the formation of a crystalline hydrate...

A - Human Necessities

61

K

167/159, 167/231

A61K 31/445 (2006.01) A61K 9/70 (2006.01) A61L 15/16 (2006.01)

Patent

CA 1331340

ABSTRACT OF THE DISCLOSURE A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.

574575

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