Method for preventing tissue damage associated with...

A - Human Necessities – 61 – K

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Details

A61K 31/573 (2006.01) A61K 31/56 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2413883

A method for preventing tissue damage associated with graft-versus-host disease in a patient having undergone hematopoietic cell transplantation, and host-versus-graft disease in a patient having undergone organ allograft transplantation. The method includes orally administering to the patient a prophylactically effective amount of a topically active corticosteroid, such as beclomethasone dipropionate, for a period of time following hematopoietic cell or organ allograft transplantation, and prior to the presentation of symptoms associated with graft-versus-host disease or host-versus-graft disease. Representative tissues includes tissue of the intestine and liver, while representative tissue damage includes inflammation thereof.

La présente invention concerne un procédé de prévention de dommages tissulaires associés à une réaction du greffon contre l'hôte chez un patient ayant subi une transplantation de cellules hématopoïétiques et associés à une réaction de l'hôte contre le greffon chez un patient ayant subi une allogreffe d'organe. Ce procédé consiste à administrer à un patient, par voie orale, une quantité à efficacité prophylactique d'un corticostéroïde à action topique, tel que le dipropionate de béclométhasone, pendant une certaine période suivant la transplantation de cellules hématopoïétiques ou l'allogreffe d'organe, et avant l'apparition de symptômes associés à une réaction du greffon contre l'hôte ou à une réaction de l'hôte contre le greffon. Des tissus représentatifs de l'invention comprennent le tissu de l'intestin et du foie et des dommages tissulaires représentatifs de l'invention comprennent l'inflammation desdits tissus.

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