Method for processing aqueous fermentation broths

C - Chemistry – Metallurgy – 12 – P

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C12P 1/00 (2006.01) B01D 19/04 (2006.01) B01D 61/16 (2006.01) C12N 1/38 (2006.01)

Patent

CA 2012767

A method for processing aqueous fermentation broths in a bioreactor vessel, in which a foam inhibitor is added to the fermentation broth in the bioreactor vessel in order to prevent the accumulation and buildup of foam in the bioreactor vessel caused by oxygen sparging of the fermentation broth contained therein. The aqueous fermentation broth processed in the bioreactor vessel is conveyed as a feed solution to an ultrafiltration system including a membrane for concentrating the aqueous fermentation broth. The ultrafiltration system is typically located downstream of the bioreactor vessel. The improvement involves reducing the amount of fouling of the membrane in the ultrafiltration system by adding to the aqueous fermentation broth in the bioreactor vessel as the foam inhibitor, an antifoam which is an oil based liquid in the form of droplets, the droplets of the oil based liquid antifoam being dispersed, encased, entrapped and imbedded, within solid particles of a water soluble encapsulating material.

Méthode de traitement d'un bouillon de fermentation aqueux dans un bioréacteur, dans lequel un antimousse est ajouté au bouillon de fermentation pour empêcher l'accumulation de mousse dans le bioréacteur résultant du barbotage à l'oxygène du bouillon de fermentation se trouvant dans le bioréacteur. Le bouillon de fermentation aqueux traité dans le bioréacteur est ajouté en tant que solution d'alimentation à un système d'ultrafiltration comportant une membrane, afin de concentrer le bouillon de fermentation aqueux. Le système d'ultrafiltration est généralement situé en aval du bioréacteur. L'amélioration proposée consiste à réduire l'encrassement de la membrane du système d'ultrafiltration en ajoutant au bouillon de fermentation aqueux se trouvant dans le bioréacteur un antimousse liquide à base d'huile, sous la forme de gouttelettes, ces dernières étant dispersées, enfermées, piégées et enrobées dans des particules solides d'une matière enrobante soluble dans l'eau.

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