Method for producing 1,2-dihydropyridine-2-one compound

C - Chemistry – Metallurgy – 07 – D

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C07D 213/64 (2006.01)

Patent

CA 2570177

Disclosed is a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III) (wherein the ring A and ring B are as defined below and the ring C represents an optionally substituted phenyl group) with high yield and high purity by reacting a compound represented by the following formula (I) (wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and X represents a leaving group) with a boronic acid derivative in the presence of a palladium compound, a copper compound, a phosphorus compound and a base.

Est décrit un procédé pour la fabrication commerciale d~un composé de 1,2-dihydropyridine-2-one représenté par la formule suivante (III) (dans laquelle le cycle A et le cycle B sont tels que définis ci-dessous et le cycle C représente un groupe phényle facultativement substitué) avec un grand rendement et une grande pureté en faisant réagir un composé représenté par la formule suivante (I) (où le cycle A représente un groupe 2-pyridyle facultativement substitué, le cycle B représente un groupe phényle facultativement substitué, et X représente un groupe labile) avec un dérivé de l'acide boronique en présence d~un composé palladium, un composé cuivre, un composé phosphore et une base.

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