Method for producing 2-chloromethylphenylacetic acid...

Details Method for producing 2-chloromethylphenylacetic acid... Method for producing 2-chloromethylphenylacetic acid...

C - Chemistry, Metallurgy

07

C

C07C 249/12 (2006.01) C07C 251/38 (2006.01)

Patent

CA 2476035

The invention relates to a method for producing 2-chloromethylphenyl acetic acid derivatives of formula (I), in which X represents C1-C4 alkoxy or methylamino, by cleaving the ether bonds in compounds of formula (II), in which R represents C1-C4 alkyl, C1-C4 alkoxy, C1-C2 alkyl halide, C1-C4 alkylcarbonyl, C1-C4 alkylcarbonyloxy, halogen, nitro or cyano, and X has the above-mentioned meaning. The inventive method is characterized in that the transformation takes place in the presence of hydrogen chloride and of an inert solvent, and in that a catalyst selected from the group comprised of: iron, indium or halogenides, oxides or triflates thereof is added to the reaction mixture.

L'invention concerne un procédé de fabrication de dérivés d'acide 2-chlorométhylphénylacétique représentés par la formule (I) dans laquelle X est C¿l?-C¿4?-alkoxy ou méthylamino, par division étherique de composés représentés par la formule (II) dans laquelle R est C¿l?-C¿4?-alkyl, C¿1?-C¿4?-alkoxy, C¿l?-C¿2?-halogénoalkyl, C¿1?-C¿4?-alkylcarbonyl, C¿l?-C¿4?-alkylcarbonyloxy, halogène, nitro ou cyano, et X possède la signification donnée plus haut. Le procédé selon l'invention est caractérisé en ce que la transformation est effectuée en présence de gaz chlorhydrique et d'un solvant inerte, et en ce qu'un catalyseur choisi dans le groupe fer, indium ou les halogénures, oxydes ou triflates de ceux-ci est additionné au mélange de réaction.

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