C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/00 (2006.01)
Patent
CA 2614239
The invention relates to a method for producing 3-arylmethylthio- and 3- heteroarylmethylthio-4,5-dihydro-isoxazoline derivatives of general formula (I), by means of a one-pot reaction wherein corresponding arylmethyl and heteroarylmethyl-isothiuronium salts are reacted in the presence of an aqueous alkali or earth alkali base with an isoxazoline derivative in order to form the corresponding 3-arylmethylthio- and 3-heteroarylmethylthio-4,5-dihydro- isoxazoline derivatives.
La présente invention concerne un procédé pour préparer des dérivés de 3-arylméthylthio- et 3-hétéroarylméthylthio-4,5- dihydro-isoxazoline de formule générale (I), par un processus en monoréacteur au cours duquel des sels d'arylméthyl- et hétéroarylméthyl-isothiuronium correspondants sont convertis en la présence d'une base aqueuse d'alcalin ou d'alcalino-terreux, avec un dérivé d'isoxazaline, pour donner les dérivés de 3-arylméthylthio- et 3-hétéroarylméthylthio-4,5-dihydro-isoxazoline correspondants.
Helmke Hendrik
Schaper Wolfgang
Bayer Cropscience Ag
Fetherstonhaugh & Co.
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