Method for producing 3-trifluoromethylphenyl-4-cyanobenzyl...

C - Chemistry – Metallurgy – 07 – C

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C07C 253/30 (2006.01) C07C 255/56 (2006.01)

Patent

CA 2482414

The invention relates to a method for producing 3-trifluoromethylphenyl-4- cyanobenzyl ketone by reacting a 3-trifluoromethyl benzoic acid-C1-C2-alkyl ester with 4-tolunitrile in an aprotic polar solvent or in an aprotic polar solvent mixture in the presence of at least one equimolar quantity of a base, whereby the base is selected among potassium alcoholates of primary C1-C4 alkanols.

L'invention concerne un procédé pour produire de la cétone 3-trifluorométhyle phényle-4-cyanobenzyle en mettant à réagir un alkylester C¿1?-C¿2 ?d'acide benzoïque 3-trifluorométhyle avec du 4-tolunitrile dans un solvant aprotique polaire ou dans un mélange de solvant aprotique polaire en présence d'au moins une quantité équimolaire d'une base, cette base étant choisie parmi des alcoolats de potassium d'alcanols C¿1?-C¿4 ?primaires.

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