Method for producing...

Details Method for producing... Method for producing...

C - Chemistry, Metallurgy

07

D

C07D 333/20 (2006.01)

Patent

CA 2556994

The invention relates to an improved method for the production of chiral N- substituted N-methyl-3-hydroxy-3-(2-thienyl)-propylamine, on an industrial scale by using asymmetric hydrogenation as a key step and, optionally, a special sequence of successive steps. A catalyst system consisting of rhodium and (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl- aminocarbonyl-pyrrolidine is used.

L'invention concerne un procédé amélioré de fabrication de N-alkyl-N-méthyl-3-hydroxy-3-(2-thiényl)-propylamine chirale N-substituée, à l'échelle industrielle, à l'aide d'une hydrogénation asymétrique constituant l'étape clé, et éventuellement d'une séquence spécifique d'étapes consécutives, faisant intervenir un système de catalyseurs composé de rhodium et de (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphényl-phosphino-méthyl)-N-méthyl-aminocarbonyl-pyrrolidine.

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