Method for producing 4- [(2',5'- diamino-6'- halopyrimidine-...

Details Method for producing 4- [(2',5'- diamino-6'- halopyrimidine-... Method for producing 4- [(2',5'- diamino-6'- halopyrimidine-...

C - Chemistry, Metallurgy

07

D

C07D 239/50 (2006.01)

Patent

CA 2348374

A novel process for preparing 4-[(2',5'-diamino-6'--halopyrimidin-4'-yl)amino]cyclopent-2-enylmethanols of the general formula (see formula I) in which X is a halogen atom, is described. According to this process, a 2,5-diamino-4,6-dihalopyrimidine of the general formula (see formula II) in which X is as defined above, is reacted with a 4-aminocyclopent-2-enylmethanol of the formula (see formula III) or one of its salts, in the presence of a base in a polar protic solvent.

L'invention concerne un nouveau procédé de 4-[(2',5'-diamino-6'-halopyrimidin-4'-yl)amino]cyclopent-2-énylméthanols de formule générale (I) dans laquelle X représente un atome d'halogène. Selon ce procédé, une 2,5-diamino-4,6-dihalopyrimidine de formule générale (II), dans laquelle X a la signification mentionnée, réagit avec un 4-aminocyclopent-2-énylméthanol de formule (III) ou avec un sel de ce dernier en présence d'une base dans un solvant polaire protique.

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