C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01)
Patent
CA 2614138
Disclosed is a method for producing 2-methyl-3-{4- [3-(1- pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone comprising a step for reacting 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazine-4-one with 4- [3-(1-pirrolidinyl)propoxy]aniline or an acid addition salt thereof, or 4-(1- cyclobutyl-4-piperidinyl)oxyaniline or an acid addition salt thereof in the presence of an acetic acid catalyst.
La présente invention concerne un procédé pour produire une 2-méthyl-3-{4- [3-(1-pyrrolidinyl)propoxy]phényl}-5-trifluorométhyl-4(3H)-quinazolinone comprenant une étape consistant à mettre en réaction du 2-méthyl-5-trifluorométhyl-4H-3,1-benzoxazine-4-one avec de la 4-[3-(1-pirrolidinyl)propoxy]aniline ou un sel d~addition acide de celle-ci, ou de la 4-(1-cyclobutyl-4-pipéridinyl)oxyaniline ou un sel d~addition acide de celle-ci en présence d~un catalyseur d~acide acétique.
Akao Atsushi
Iida Takehiko
Itoh Takahiro
Kadowaki Chie
Mase Toshiaki
Banyu Pharmaceutical Co. Ltd.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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