C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2397767
2. The present invention relates to a process process for the preparation of the compound of the formula I (see formula I) where the compound of the formula III (see formula III) is reacted with oxalyl chloride and the product obtained is treated with hydrazine and an alkali metal hydroxide in the aqueous phase at elevated temperature, after treatment is complete a three-phase system is produced by addition of an ether and the compound of the formula I is obtained by acidifying the middle phase. The invention moreover relates to a polymorph of the compound of the formula I.
L'invention concerne un procédé pour préparer un composé de formule (I), selon lequel on fait réagir le composé de formule (III) avec du chlorure d'oxalyle et l'on traite le produit obtenu avec de l'hydrazine et un hydroxyde de métal alcalin en phase aqueuse à une température élevée, puis, une fois le traitement effectué, on produit un système à 3 phases par addition d'un éther, et on obtient le composé de formule (I) par acidification de la phase centrale. L'invention concerne également une forme polymorphe du composé de formule (I).
Kammermeier Thomas
Laufer Stefan
Merckle Philipp
Striegel Hans-Gunter
Deeth Williams Wall Llp
Merckle Gmbh
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