C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/52 (2006.01) A61K 31/40 (2006.01) C07B 37/10 (2006.01)
Patent
CA 2347757
The invention relates to a method for producing (+)-exo-6-phenyl-3--azabicyclo- [3.2.0]heptanes of formula (I) in which R represents hydrogen, chlorine, bromine, fluorine or methoxy. The inventive compounds are characterized in that a bisallyl ammonium salt of formula (II), in which R has the above-mentioned meanings and X- represents an anion, is photo-cyclized in an inert solvent while adding a sensitizer in a glass apparatus, and the selected (+)-exo-isomer (I) is precipitated as ditoluoyl tartrate using (-)-ditoluoyl tartaric acid from the obtained mixture, and this ditoluoyl tartrate is optionally recrystallized out of an alcohol/water mixture.
L'invention concerne un procédé de production de (+)-exo-6-phényl-3-azabicyclo-[3.2.0]heptanes correspondant à la formule (I), dans laquelle R représente hydrogène, chlore, brome, fluor ou méthoxy. Ce procédé se caractérise en ce que l'on photocyclise un sel de bisallylammonium correspondant à la formule (II), dans laquelle R a la signification susmentionnée et X<-> représente un anion, dans un solvant inerte, avec addition d'un sensibiliseur, dans un appareillage en verre, en ce que l'on fait précipiter, avec de l'acide (-)-ditoluoyltartrique, à partir du mélange obtenu, le (+)-exo-isomère (I) désiré, sous forme de tartrate de titoluoyle, et en ce que, éventuellement, on fait recristalliser cet isomère à partir d'un mélange alcool/eau.
Bischof Norbert
Buschmann Ernst
Henningsen Michael
Krei Georg Arnold
Munschauer Rainer
Abbott Gmbh & Co. Kg
Basf Aktiengesellschaft
Robic
LandOfFree
Method for producing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for producing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1657034