Method for producing a 2-(ethoxymethyl)tropane derivative

Details Method for producing a 2-(ethoxymethyl)tropane derivative Method for producing a 2-(ethoxymethyl)tropane derivative

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01)

Patent

CA 2554125

The invention relates to a method for producing a 2-(ethoxymethyl)tropane derivative or a pharmaceutically acceptable salt thereof. The inventive is method is characterized by treating the corresponding 2-(hydroxymethyl)tropane derivative with ethyl bromide in the presence of a base, a phase transfer catalyst, and optionally a diluent and then optionally with an acid.

L'invention concerne un procédé pour produire un dérivé de 2-(éthoxyméthyl)tropane de formule (I) ou un de ses sels pharmaceutiquement acceptables. Le procédé de l'invention comprend le traitement du dérivé de 2-(hydroxyméthyl)tropane correspondant avec du bromure d'éthyle en présence d'une base, d'un catalyseur de transfert de phase, et éventuellement un diluant, puis éventuellement le traitement au moyen d'un acide.

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