Method for producing a 3,5-dihydroxy-6-heptenoate

Details Method for producing a 3,5-dihydroxy-6-heptenoate Method for producing a 3,5-dihydroxy-6-heptenoate

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01)

Patent

CA 2499335

A method for producing an alkyl (3R,5S)-7-[2-cyclopropyl-4-(4- fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate of the formula (1) (wherein R is a C1-4 alkyl group), which is an intermediate for a cholesterol- reducing agent (a HMG-CoA reductase inhibitor), etc. A solution containing a compound of the formula (1) is subjected to liquid chromatography treatment using silica gel as the packing material, to separate its epimers contained therein.

L'invention concerne un procédé de fabrication d'un alkyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate représenté par la formule (1) (R étant un groupe C¿1-4? alkyl), qui est produit intermédiaire d'un agent réducteur de cholestérol (un inhibiteur de réductase HMG-CoA), etc. Une solution contenant un composé de la formule (1) est soumise à un traitement chromatographique liquide au moyen de gel de silice en tant que remplissage, afin de séparer les épimères contenues dedans.

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