Method for producing a vaccine

Details Method for producing a vaccine Method for producing a vaccine

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 39/39 (2006.01) A61P 37/00 (2006.01) C07K 16/06 (2006.01) C07K 16/42 (2006.01)

Patent

CA 2441499

The invention relates to a method for producing a vaccine, which contains autologous antibodies, characterized by the following steps: preparing a liquid that contains antibodies from a body fluid containing autologous antibodies or from autologous cell preparations or tissue preparations; treating the liquid that contains antibodies with a solid support, on which ligands are immobilized that bond to a defined group of antibodies, with the stipulation that the ligands used are not antibodies or fragments thereof with the same idiotype, directed against tumor-associated antigens; obtaining the antibodies that bond to the ligands, and; processing the obtained antibodies to form an autologous vaccine, which contains an efficient amount of antibodies ranging from several micrograms to one gram.

L'invention concerne un procédé permettant de produire un vaccin contenant des anticorps autologues, qui se caractérise en ce qu'il comporte les étapes suivantes : préparer un liquide contenant des anticorps, à partir d'un liquide organique contenant des anticorps autologues ou à partir de préparations cellulaires ou tissulaires autologues ; traiter le liquide contenant les anticorps avec un support solide, sur lequel sont immobilisés des ligands qui induisent des liaisons avec un groupe déterminé des anticorps, sous réserve que les ligands utilisés ne soient par des anticorps ou leurs fragments de même idiotype, dirigés contre des antigènes associés à des tumeurs ; produire les anticorps qui induisent une liaison avec les ligands ; traiter les anticorps obtenus pour former un vaccin autologue contenant une quantité efficace de l'ordre de quelque microgrammes à un gramme d'anticorps.

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