Method for producing acetamidopyrrolidine derivative and...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/14 (2006.01) C07C 231/02 (2006.01) C07C 231/12 (2006.01) C07C 235/52 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2570179

Disclosed is a method for producing an acetamidopyrrolidine derivative or a salt thereof comprising a reaction process expressed by the following formulae. Formulae In the formulae, R1 represents a hydrogen atom or a C1-C6 alkyl group; R13, R14, R15 and R16 independently represent a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group, a hydroxy group, a C1- C6 halogenated alkyl group or a C1-C6 halogenated alkoxy group; and R21 represents an ester-protecting group.

La présente invention décrit un procédé de production d~un dérivé d~acétamidopyrrolidine ou d~un sel de ce dérivé qui comprend un procédé réactionnel exprimé par les formules suivantes. Formules. Dans les formules, R?1¿ représente un atome d~hydrogène ou un groupe alkyle en C¿1? à C¿6 ?; R?13¿, R?14¿, R?15¿ et R?16¿ représentent indépendamment un atome d~hydrogène, un atome d~halogène, un groupe alkyle en C¿1? à C¿6?, un groupe alcoxy en C¿1? à C¿6?, un groupe hydroxy, un groupe alkyle halogéné en C¿1? à C¿6? ou un groupe alcoxy halogéné en C¿1? à C¿6? ; et R?21¿ représente un groupe de protection d~un groupe ester.

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