C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C12N 9/78 (2006.01) C12P 7/42 (2006.01)
Patent
CA 2433036
The present invention relates to a method for producing .alpha.-hydroxy acids from the corresponding .alpha.-hydroxy nitrile using a catalyst having nitrilase activity. More specifically, the invention pertains to use of Acidovorax facilis 72W (ATCC 55746) nitrilase to hydrolyze glycolonitrile to glycolic acid, or acetone cyanohydrin to 2-hydroxyisobutyric acid. Glycolonitrile is reacted in an aqueous mixture with a catalyst having Acidovorax facilis 72W nitrilase activity to give glycolic acid selectively, and at high concentration and high yield.-hydroxy nitrile using a catalyst having nitrilase activity. More specifically, the invention pertains to use of Acidovorax facilis 72W (ATCC 55746) nitrilase to hydrolyze glycolonitrile to glycolic acid, or acetone cyanohydrin to 2-hydroxyisobutyric acid. Glycolonitrile is reacted in an aqueous mixture with a catalyst having Acidovorax facilis 72W nitrilase activity to give glycolic acid selectively, and at high concentration and high yield.
La présente invention concerne un procédé de production d'alphahydroxyacides à partir de l'alphahydroxynitrile correspondant à l'aide d'un catalyseur ayant une activité nitrilase. De manière plus spécifique, cette invention concerne l'utilisation de la nitrilase de Acidovorax facilis 72W (ATCC 55746) pour hydrolyser le glyconitrile en acide glycolique, ou bien la cyanohydrine d'acétone en acide 2-hydroxyisobutyrique. Le glyconitrile réagit dans un milieu aqueux avec un catalyseur ayant une activité nitrilase de Acidovorax facilis 72W pour produire sélectivement de l'acide glycolique à une forte concentration et un rendement élevé.
Chauhan Sarita
Dicosimo Robert
Fall0n Robert D.
Gavagan John E.
Payne Mark S.
Bennett Jones Llp
E. I. Du Pont de Nemours And Company
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