C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/102, 260/103
C07D 501/20 (2006.01) C07D 499/00 (2006.01)
Patent
CA 1118412
ABSTRACT OF THE DISCLOSURE Novel esters of the formula 1, salts of the esters of such for- mula I with pharmaceutically acceptable acids, and processes for producing such new compounds are provided herein. The novel esters have the for- mula I Image I in which R1 and R2 represent C1-7 alkyl or together with the nitrogen form a heterocyclic radical having 4 to 8 carbon atoms; R3 represents hydrogen or benzyl; R5 represents hydrogen acyloxy, carbamoyloxy, or SR8, where R8 stands for a heterocyclic ring; R6 represents methyl substituted by cyano, pyridylthio, trifluoromethyl or by a 5-membered heterocyclic ring, or simultaneously by a 5-membered heterocyclic ring and by methoximino or represents benzyl substituted by azido, amino and/or hydroxy or represents 1,4-cyclohexadienylmethyl substitued by amino; and R7 represents hydrogen or methoxy. The novel compounds described above posses valuable in vivo antibacterial activity and their toxicity is low, even when administered parenterally.
272706
Binderup Ernst T.
Godtfredsen Wagn O.
Leo Pharmaceutical Products Ltd. A/s (lovens Kemiske Fabrik Prod
Marcus & Associates
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