Method for producing analgesia comprising administration of...

A - Human Necessities – 61 – K

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Details

A61K 31/485 (2006.01) A61K 31/4436 (2006.01) A61K 31/4468 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61M 5/142 (2006.01) A61M 5/168 (2006.01)

Patent

CA 2490386

A method of producing analgesia in a mammal is provided by rotational (alternating) intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist, such as a µ-, .delta.- or .kappa.-opioid receptor agonist for a first period of time, followed by intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor-like receptor 1 (ORL-1) agonist for a second period of time. The intrathecal drug administration of the first and second periods of time may be repeated a plurality of times without attaining tolerance in the mammal to either drug. Implantable apparatus for rotational administration of the active agents is also disclosed.

Procédé visant à produire une analgésie chez un mammifère, par l'administration intrathécale alternée à ce mammifère d'une dose pharmaceutiquement efficace d'au moins un agoniste de récepteur des opioïdes, tel qu'un agoniste de récepteur mu , delta ou kappa , pendant une première période, suivie par l'administration intrathécale d'une dose pharmaceutiquement efficace d'au moins un agoniste de récepteur 1 du type récepteur aux opioïdes pendant une deuxième période. L'administration intrathécale des médicaments des deux périodes peut être répétée une pluralité de fois sans atteindre la tolérance du mammifère à l'un ou l'autre des médicaments. L'invention concerne aussi un dispositif implantable d'administration alternée des principes actifs.

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