Method for producing (aryl substituted) carboxylic acid or...

C - Chemistry – Metallurgy – 07 – C

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260/515.3, 260/5

C07C 57/30 (2006.01) C07C 51/29 (2006.01) C07C 51/487 (2006.01) C07C 59/66 (2006.01) C07C 59/84 (2006.01)

Patent

CA 1303060

ABSTRACT OF THE DISCLOSURE An effective method for producing highly pure (aryl substituted) carboxylic acid such as (aryl substituted) propionic acid or a salt thereof, which comprises the steps of: oxidizing (aryl substituted)aldehyde in an acidic phase in the presence of hypohalogenite; and bringing the oxidized product obtained in the preceding step into contact in a liquid phase with hydrogen in the presence of a catalyst of transition metal of the group VIII in the periodic table. The product of the present invention can be used as an intermediate material for preparing anti-inflammatory medicines of 2-(4- isobutylphenyl)propionic acid (Ibuprofen) and 2-(3- benzoylphenyl)propionic acid (Ketoprofen).

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