Method for producing benzylidene derivatives

Details Method for producing benzylidene derivatives Method for producing benzylidene derivatives

C - Chemistry, Metallurgy

07

D

C07D 275/02 (2006.01) C07D 265/02 (2006.01) C07D 291/06 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 419/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2124136

The present invention is directed to a selective method for producing given stereoisomeric benzylidene derivatives of the formula III: Image wherein R1 and R2 each independently is lower alkyl, lower alkoxy or halogen; Y is SO2, SO or CO; -A- is optionally substituted lower alkylene; -B- is -CH2- or -O-; or -A- and -B- taken together may form optionally substituted phenylene or optionally substituted lower alkenylene; and R is hydrogen, optionally substituted lower alkyl, cycloalkyl, lower alkoxy, hydroxy, optionally substituted aryl, optionally substituted arylalkyl; optionally substituted arylalkyloxy, a heterocyclic ring or N-protecting groups, which comprises reacting a compound of the formula I: Image - 2 - wherein R1 and R2 are as defined above and X is lower alkoxy or halogen with a compound of the formula II: Image wherein Y, -A-, -B- and R are as defined above in the presence of a base. The compounds of the present invention are useful as non-steroidal anti-inflammatory agents.

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