C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 19/00 (2006.01) C12N 15/67 (2006.01) C12P 21/02 (2006.01) C12P 21/06 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2213512
Disclosed is a method for producing a bioactive fusion protein, whereby a novel bioactive fusion protein can be efficiently produced by selectively using an optimal linker polypeptide. The bioactive fusion protein can be applied to therapeutic or diagnostic agents or gene therapy. The method of the present invention for producing bioactive fusion protein is characterized by culturing a transformant obtained by transformation with an expression vector containing a DNA sequence encoding an amino acid sequence of a protein represented by the following formula: A-X-B (wherein A and B represent respectively subunits of a dimer protein or bioactive monomers in their native form, where A and B may represent the same, and X represents a linker polypeptide).
L'invention porte sur un procédé de production de protéines fusionnées, biologiquement actives, pouvant servir de remède ou d'agent diagnostique ou s'appliquer à la thérapie génique, et s'obtenant par une sélection du polypeptide de liaison le mieux approprié. Ledit procédé consiste à incuber des transformants obtenus par la transformation de vecteurs d'expression contenant des séquences d'ADN codant pour les séquences d'acides aminés de protéines de formule A-X-B où A et B, qui peuvent être identiques, représentent respectivement les sous-unités d'une protéine dimère ou de protéines biologiquement actives, et X, le polypeptide de liaison.
Akiyama Hideo
Fujiwara Hiromi
Kanai Shozo
Nakatani Izumi
Tomura Michio
Smart & Biggar
Toray Industries Inc.
Toray Research Center Inc.
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