Method for producing chemical compounds

Details Method for producing chemical compounds Method for producing chemical compounds

C - Chemistry, Metallurgy

07

D

260/114.7

C07D 499/68 (2006.01) C07D 499/00 (2006.01)

Patent

CA 1178574

ABSTRACT OF THE DISCLOSURE Novel processes are provided herein for the preparation of a new salt of the antimicrobial agent 1,1-dioxopenicillanoyloxymethyl 6-(D-.alpha.- amino-.alpha.-phenylacetamido)penicillanate, more particularly the salt with 2- naphthalenesulfonic acid, and in particular this salt in crystalline, hy- drated form, preferably the monohydrate, According to this invention, the salt is easily obtained in a crystalline state devoid of organic solvent residues, it shows good stability on storage, it is effectively absorbed and hydrolyzed in vivo, and it is thus specifically suitable for medical treatment of patients, in particular for oral administration.

386593

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