Method for producing composition for solid medicine

Details Method for producing composition for solid medicine Method for producing composition for solid medicine

A - Human Necessities

61

K

A61K 47/38 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 31/35 (2006.01) A61K 31/353 (2006.01) A61K 31/4025 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01)

Patent

CA 2148220

ABSTRACT OF THE DISCLOSURE In producing a composition for solid medicine, comprising, as an active ingredient, a potassium channel activator and a pharmaceutically acceptable water-insoluble cellulose polymer, a method for producing a composition for solid medicine, which is characterized by dissolving a potassium channel activator in a solvent to give a medical solution, adding said medical solution to a water-insoluble cellulose polymer inert to said solvent in an amount necessary and sufficient to achieve a predetermined elution rate, homogeneously mixing them and drying the mixture to remove the solvent, and a composition for solid medicine, which is obtainable by said production method. According to the method of the present invention, elution rate of the active ingredient of a preparation comprising a potassium channel activator, which is a sustained release preparation, can be controlled with ease and with good reproducibility. 1 9

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