A - Human Necessities – 61 – J
Patent
A - Human Necessities
61
J
A61J 3/02 (2006.01) A61K 9/14 (2006.01) C07J 75/00 (2006.01)
Patent
CA 2480130
The invention relates to a method for producing crystallines from active ingredients in medicaments, the average particle size thereof lying within a given range and the maximum particle size thereof not exceeding a given value. During crystallisation, an oversaturated solution is subjected to wet milling by means of a wet milling device; as a result, a primary grain suspension is obtained. The invention also relates to crystals obtained according to said method and pharmaceutical formulations containing said crystals.
L'invention concerne un procédé de production de cristaux de principes actifs de médicaments, dont la taille moyenne des particules se situe dans une plage donnée et dont la taille maximale des particules ne dépasse pas une valeur donnée. Une solution sursaturée pendant la cristallisation est soumise à un broyage humide à l'aide d'un dispositif de broyage humide, ce qui permet d'obtenir une suspension de grains primaire. L'invention concerne également les cristaux obtenus selon ce procédé et les formulations pharmaceutiques les contenant.
Eichardt Annette
Gerecke Hagen
Gliesing Sabine
Grawe Detlef
Hoesel Peter
Fetherstonhaugh & Co.
Schering Aktiengesellschaft
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