C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/04 (2006.01) C12N 1/20 (2006.01) C12P 13/24 (2006.01) C12P 17/10 (2006.01) C12P 17/12 (2006.01) C12P 41/00 (2006.01)
Patent
CA 2299324
The invention relates to new microorganisms capable of utilising a N-protected cyclic amino acid derivative, selected from the compounds of the general formula (I), in the form of the racemate or one of its optical isomers, where A together with -N- and -CH is a possibly substituted 4-, 5-, 6-, or 7- membered heterocyclic ring and R1 is a possibly substituted alkyl, alkoxy, aryl or aryloxy, and/or are capable of hydrolizing a N-protected cyclic amino acid derivative, selected from among the compounds of the general formula (I), as well as to enzyme extracts thereof. The invention also relates to a new method for producing N-protected cyclic L-amino acid derivatives and cyclic D- amino acids by using said microorganisms.
L'invention concerne de nouveaux micro-organismes capables d'utiliser, sous forme d'une source C unique ou d'une source N unique, ou d'une source C et N, un dérivé aminoacide cyclique N-protégé, choisi parmi des composés de formule générale (I), sous forme du racémate ou de l'un de ses isomères optiques, dans laquelle A désigne, conjointement avec -N- et -CH-, un noyau hétérocyclique saturé à 4, 5, 6 ou 7 chaînons éventuellement substitué, et R?1¿ désigne un alkyle, alcoxy, aryle ou aryloxy, respectivement, éventuellement substitué, et/ou capables d'hydrolyser un dérivé aminoacide cyclique N-protégé, ainsi que des extraits enzymatiques de ces produits. L'invention concerne en outre un nouveau procédé de fabrication de dérivés de L-aminoacides cycliques N-protégés et de D-aminoacides cycliques en utilisant lesdits micro-organismes.
Sauter Martin
Werbitzky Oleg
G. Ronald Bell & Associates
Lonza Ag
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