Method for producing cyclic lactic acid oligomer

Details Method for producing cyclic lactic acid oligomer Method for producing cyclic lactic acid oligomer

C - Chemistry, Metallurgy

07

D

C07D 323/00 (2006.01) A61K 31/365 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07B 61/00 (2006.01) C07D 319/12 (2006.01)

Patent

CA 2385318

A process for the preparation of cyclic lactic acid oligomers represented by general formula (1) characterized by polymerizing lactide in the presence of an alkali metal compound represented by the formula (2): R-Y-Me (wherein R is an aliphatic group, an aromatic group, -Si(R10)(R11)(R12), -CH(R20)CONR21R22, or -CH(R30)COOR31; Y is -O-, -S-, or -NR40-; and Me is an alkali metal); and cyclic lactic acid oligomers prepared by the process.

L'invention concerne un procédé de préparation d'oligomères cycliques d'acide lactique représentés par la formule générale (1). Ce procédé consiste à polymériser un lactide en présence d'un composé de métal alcalin représenté par la formule générale (2): R-Y-Me, dans laquelle R est un groupe aliphatique, un groupe aromatique, -Si(R?10¿)(R?11¿)(R?12¿), -CH(R?20¿)CONR?21¿R?22¿, ou -CH(R?30¿)COOR?31¿, Y est -O-, -S- ou -NR?40¿-, et Me est un métal alcalin. L'invention concerne également des oligomères cycliques d'acide lactique préparés selon ce procédé.

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