Method for producing cytidine monophosphate of 5-...

C - Chemistry – Metallurgy – 12 – P

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C12P 19/38 (2006.01)

Patent

CA 1243971

ABSTRACT OF THE DISCLOSURE Cytidine monophosphate of 5-acetamido-3,5-dideoxy-D- glycero-D-galactononulosaminic acid is produced by an improved method by the condensation of cytidine triphosphate (CTP) with N-acetylneuraminic acid (NANA), catalyzed by the enzyme CMP- transferase (CMP-acylneuraminate synthase) (EC 2.7.7.43), either (A) in the presence of a thiocarboxylic acid or nitro- imidazole stabilizer or (B) using the enzyme isolated from the E. coli strain CRC 1482. The product can be used as an active substance in pharmaceutical compositions for use in the therapy of pathological states related to disturbances of the nervous stimulus in the central (CNS) and peripheral (PNS) nervous system.

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