Method for producing doxazodin mesylate in a crystal...

Details Method for producing doxazodin mesylate in a crystal... Method for producing doxazodin mesylate in a crystal...

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/505 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2317523

Disclosed is a method for the production of doxazodin mesylate according to modification A, wherein doxazodin is dissolved with methanesulfonic acid in methanol or in a mixture of an aprotic polar organic solvent and methanol. Turbidity is optionally eliminated in the solution thus obtained. The resulting clear solution is stirred until no precipitation occurs and it is then separated and washed with methanol. The wet precipitate is then heated in ethanol and the resulting product is isolated after cooling.

L'invention concerne un procédé de fabrication de mésylate de doxazosine selon une modification A, caractérisé en ce qu'on dissout la doxazosine avec de l'acide méthanesulfonique dans le méthanol ou avec un mélange d'un solvant organique polaire aprotique et de méthanol, en ce que la solution ainsi obtenue est éventuellement débarrassée d'un trouble, en ce qu'on agite la solution limpide qui se présente alors, jusqu'à l'absence de précipité, on sépare ensuite la solution du précipité, on lave au méthanol, on chauffe le précipité à l'état humide dans l'éthanol et, après refroidissement, on isole le produit formé.

Affiliated with

Also associated with

Rating

Method for producing doxazodin mesylate in a crystal... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for producing doxazodin mesylate in a crystal..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for producing doxazodin mesylate in a crystal... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1883656