Method for producing epitomers and their uses on carrier...

Details Method for producing epitomers and their uses on carrier... Method for producing epitomers and their uses on carrier...

C - Chemistry, Metallurgy

12

N

C12N 15/64 (2006.01) A61K 39/00 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) C12N 15/74 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2638834

The present invention relates to a method for producing carrier microorganisms, in particular bacteria, which, through targeted genetic manipulation, carry epitopes or epitomers, respectively, on their surfaces. Epitomers are antigenically effective epitopes that can be found in the polypeptide chain in multiple identical copies, and which, when expressed on the surface of the bacteria, can be used for immunization with particular success. A further aspect relates to correspondingly produced bacteria and their uses as vaccines, in particular in cancer therapy.

La présente invention concerne un procédé de production de micro-organismes porteurs, en particulier de bactéries, qui, par le biais d'une manipulation génétique ciblée, portent respectivement des épitopes ou épitomères sur leur surface. Les épitomères sont des épitopes efficaces en termes d'antigénicité qui se trouvent en de multiples copies identiques au niveau de la chaîne polypeptidique, et qui, une fois exprimés sur la surface des bactéries, peuvent être utilisés pour une immunisation remportant un succès particulier. Un autre aspect de l'invention concerne des bactéries produites de manière correspondante et leurs utilisations en tant que vaccins, notamment en cancérothérapie..

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