Method for producing epothilone b and derivatives, and...

Details Method for producing epothilone b and derivatives, and... Method for producing epothilone b and derivatives, and...

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) C07D 277/24 (2006.01) C07D 303/00 (2006.01) C07D 313/00 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2346493

The invention relates to a method for producing epothilone B and derivatives, and to intermediate products for this method. According to the novel method, the epothilone B or derivatives are produced in high yields from the C1-C6, C7- C10 and C11-C20-fragments 2, 3 and 4 that can be obtained economically and diastereomerically purely (the variable radicals having the meanings given in the description ).

L'invention concerne un procédé permettant de préparer de l'épothilone B et des dérivées, ainsi que des produits intermédiaires utilisés pour ledit procédé. Selon ce procédé, l'épothilone B ou les dérivés sont obtenus dans des rendements élevés à partir de fragments de C¿1?-C¿6?, C¿7?-C¿10? et C¿11?-C¿20? (2, 3 et 4) (les restes variables ayant les significations mentionnées dans la description).

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