Method for producing finely pulverized organic compound...

Details Method for producing finely pulverized organic compound... Method for producing finely pulverized organic compound...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 31/015 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/4174 (2006.01) A61K 31/4422 (2006.01) A61K 31/4704 (2006.01) A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61K 31/573 (2006.01) A61K 47/04 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2679929

Disclosed is a method for producing pulverized particles of a crystalline organic compound which is poorly water soluble. Also disclosed is a pulverized organic compound particle produced by such a method. Specifically disclosed is a method for producing a poorly water-soluble organic compound particle for medical use, which is characterized in that a poorly water-soluble organic compound for medical use is mixed with a physiologically acceptable salt and a physiologically acceptable polyol, and subjected to wet milling. Also specifically disclosed is a poorly water-soluble organic compound particle for medical use, which is produced by such a production method.

L'invention concerne un procédé de production de particules pulvérisées d'un composé organique cristallin faiblement soluble dans l'eau. Une particule pulvérisée de composé organique produite par un tel procédé est également décrite. Un procédé pour produire une particule faiblement soluble dans l'eau de composé organique faiblement soluble dans l'eau et à usage médical est spécifiquement décrit. Ledit procédé est caractérisé en ce qu'un composé organique faiblement soluble dans l'eau et à usage médical est mélangé à du sel physiologiquement acceptable et à un polyol physiologiquement acceptable, et soumis à un broyage par voie humide. Une particule faiblement soluble dans l'eau de composé organique à usage médical produite par un tel procédé de production est également spécifiquement décrite.

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