Method for producing heterocyclic compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 417/06 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2402467

The present invention relates to a process for the preparation of compounds of the formula (I) (see formula I) in which R1, A, D, X and Z have the meanings given in the description, by reacting compounds of the formula (II) (see formula II) in which A, D and X have the meanings given above, with a base and in the presence of a diluent, and subsequently reacting the reaction mixture with the mixture of CCMP/CMP (2-chloro-5-chloromethylpyridine/2-chloro- 5-methylpyridine) and the corresponding hydrochlorides.

La présente invention concerne un procédé de production de composés de formule (I), dans laquelle R<1>, A, D, X et Z ont les significations données dans la description de cette invention, par réaction de composés de formule (II), dans laquelle A, D et X ont les significations données ci-dessus, avec une base, en présence d'un diluant, puis par réaction du mélange réactionnel avec le mélange constitué de CCMP/CMP (2-chloro-5-chlorométhylpyridin/2-chloro-5-méthylpyridine) et des hydrochlorures correspondants.

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