Method for producing human-derived immunocompetent cells

Details Method for producing human-derived immunocompetent cells Method for producing human-derived immunocompetent cells

A - Human Necessities

01

K

A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2529488

It is intended to provide an immunodeficient animal capable of producing human- origin lymphocytes, a human-origin lymphocyte and a process for producing an antibody specific to a human antigen. Namely, an immature immunodeficient mammal having human-origin hematopoietic precursor cells transplanted thereinto that can produce hematopoietic cells or immunocompetent cells originating in the above human; and a process for producing an antibody characterized by comprising collecting immunocompetent cells from the above animal, culturing the immunocompetent cells and then harvesting a human-origin antibody from the culture thus obtained.

L'invention concerne un animal immunodéficitaire capable de produire des lymphocytes d'origine humaine, un lymphocyte d'origine humaine et une méthode permettant de produire un anticorps spécifique d'un antigène humain. D'une manière plus spécifique, l'invention concerne, d'une part, un mammifère immunodéficitaire immature dans lequel ont été transplantées des cellules précurseurs hématopoïétiques d'origine humaine, lequel mammifère peut produire des cellules hématopoïétiques ou des cellules immunocompétentes d'origine humaine et, d'autre part, une méthode permettant de produire un anticorps caractérisée en ce qu'elle consiste à prélever des cellules immunocompétentes sur ledit animal, à cultiver ces cellules immunocompétentes, puis à récolter un anticorps d'origine humaine de la culture ainsi obtenue.

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