Method for producing in vivo proteins chemically diversified...

C - Chemistry – Metallurgy – 12 – P

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C12P 21/02 (2006.01) C12N 15/10 (2006.01) C12N 15/67 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2347993

The invention concerns processes enabling prokaryotic or eukaryotic cells to acquire the capacity to produce proteins whereof the amino acid sequences comprise at least a non-standard amino acid, methods for selecting said cells, methods for producing and purifying said proteins and cells and proteins obtained by said methods and processes. The invention also concerns uses of said cells and proteins in various fields such as therapeutics, cosmetics, diagnosis or biosynthesis or biodegradation of organic compound.

L'invention a pour objet des méthodes permettant à des cellules procaryotes ou eucaryotes d'acquérir la capacité de produire des protéines dont les séquences d'acides aminés comprennent au moins un acide aminé non conventionnel, des méthodes de sélection desdites cellules, des procédés de production et de purification desdites protéines ainsi que les cellules et les protéines obtenues par les méthodes et procédés selon l'invention. L'invention comprend également les applications desdites cellules et protéines dans différents domaines tels que le domaine thérapeutique, cosmétique, diagnostic ou de la biosynthèse ou la biodégradation de composé organique.

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