Method for producing indole derivative having piperidine ring

Details Method for producing indole derivative having piperidine ring Method for producing indole derivative having piperidine ring

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) C07D 311/22 (2006.01)

Patent

CA 2607907

It is possible to commercially advantageously produce 1-{1-[2-(7-methoxy-2,2- dimethyl-4-oxochroman-8-yl)ethyl] piperidin-4-yl}-N-methyl-1H-indole-6- carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8- yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy- 2,2-dimethylchroman-4-one, with N-methyl-1-(piperidin-4-yl)- 1H-indole-6- carboxamide.

La présente invention décrit une synthèse avantageuse du point de vue commercial du 1-{1-[2-(7-méthoxy-2,2-diméthyl-4-oxochroman-8-yl)éthyl]pipéridin-4-yl}-N-méthyl-1H-indole-6-carboxamide par le couplage entre le (7-méthoxy-2,2-diméthyl-4-oxochroman-8-yl)acétaldéhyde, obtenu par oxydation de la 8-(2-hydroxyéthyl)-7-méthoxy- 2,2-diméthylchroman-4-one, et le N-méthyl-1-(pipéridin-4-yl)-1H-indole-6-carboxamide.

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