Method for producing indole derivatives on a solid phase

Details Method for producing indole derivatives on a solid phase Method for producing indole derivatives on a solid phase

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) C07B 61/00 (2006.01) C07D 209/14 (2006.01) C07D 209/20 (2006.01) C07D 209/42 (2006.01) C07D 405/04 (2006.01) C07F 7/22 (2006.01)

Patent

CA 2386074

The invention relates to a method for producing indole derivatives on a solid phase. Binding to the solid phase is carried out on indole nitrogen by means of a transacetalisation of dialkoxymethyl-protected indoles with a solid phase that carries vivinal diole groups. After synthetic chemistry on the solid phase, the functionalised indole derivative is separated from the solid phase in a traceless manner.

Procédé de préparation de dérivés d'indol sur une phase solide, selon lequel la liaison à la phase solide se produit au niveau de l'azote de l'indol par transacétalisation d'indols à protection dialcoxyméthyle avec une phase solide qui porte des groupes diol vicinaux. Après que la phase solide a été soumise à la chimie de synthèse, le dérivé d'indol fonctionnalisé est séparé <= sans traces >= de ladite phase solide.

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