Method for producing l-phenylephrine using an alcohol...

Details Method for producing l-phenylephrine using an alcohol... Method for producing l-phenylephrine using an alcohol...

C - Chemistry, Metallurgy

12

P

C12P 41/00 (2006.01) C12P 13/00 (2006.01)

Patent

CA 2735769

The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2- methylamino-ethyl]-phenol.

La présente invention concerne un procédé de préparation en plusieurs étapes d'alcools optiquement actifs substitués, comprenant une étape de synthèse catalysée par enzyme, en particulier par l'alcool déshydrogénase. Le procédé selon l'invention est adapté en particulier pour préparer de la phényléphrine, c.-à-d. du 3-[(1R)-1-hydroxy-2-méthylamino-éthyl]-phénol.

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